Most Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. LOSARTAN; HYDROCHLOROTHIAZIDE (loe SAR tan; hye droe klor oh THYE a zide) is a combination of a drug that relaxes blood vessels and a diuretic. If you log out, you will be required to enter your username and password the next time you visit. Find patient medical information for Losartan-Hydrochlorothiazide Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Sign up now. The above information is provided for general If dose titrated upward, not to exceed final titration of 100 mg/25 mg PO qDay or 50 mg/12.5 mg PO q12hr, Decrease losartan to 25 mg PO qDay initially if volume depleted, Treat with losartan monotherapy; if reduction in blood pressure inadequate, initiate losartan /hydrochlorothiazide, Initial: 50 mg/12.5 mg PO qDay; may increase to 100 mg/12.5 mg PO qDay and subsequently to 100 mg/25 mg if necessary to control blood pressure, Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system, causing oligohydramnios, which may result in fetal injury and/or death (see Pregnancy & Lactation), Hypersensitivity to losartan, hydrochlorothiazides, or sulfonamides, Coadministration with aliskiren in patients with diabetes, In patients with activated renin-angiotensin system, such as volume-or salt-depleted patients (eg, those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment; correct volume or salt depletion prior to administration; do not use drug combination as initial therapy in patients with intravascular volume depletion, Stroke risk reduction may be less effective in African-Americans, Intravascular volume or salt depletion should be corrected prior to use, Monitor serum lithium levels in patients receiving lithium and hydrochlorothiazide, Inform female patients of childbearing age about consequences of exposure to losartan during pregnancy and importance of informing their physician about a pregnancy while on therapy; discontinue if pregnancy detected, Monitor for signs of fluid or electrolyte imbalance, including hyponatremia, hypomagnesemia, hypochloremic alkalosis, and hypokalemia, Hydrochlorothiazide may alter glucose tolerance and raise serum levels of cholesterol and triglycerides, If oliguria or hypotension occurs in neonate with history of in utero exposure, direct attention toward support of blood pressure and renal perfusion; exchange transfusions or dialysis may be required as a means of reversing hypotension and/or substituting for disordered renal function, Acute transient myopia and acute angle-closure glaucoma have been reported, particularly with history of sulfonamide or penicillin allergy (hydrochlorothiazide is a sulfonamide), Coadministration with corticosteroids, ACTH, or glycyrrhizin (found in liquorice) may intensify electrolyte depletion, particularly hypokalemia, Monitor renal function and potassium in susceptible patients, Exacerbation of systemic lupus erythematosus reported, Dual blockade of the renin-angiotensin-aldosterone system (ie, ARB plus an ACE inhibitor) in patients with established atherosclerotic disease, heart failure, or with diabetes with end organ damage is associated with a higher frequency of hypotension, syncope, hyperkalemia, and changes in renal function (including acute renal failure) as compared with use of a single renin-angiotensin-aldosterone system agent; closely monitor blood pressure, renal function and electrolytes in patients on losartan and other agents that affect the renin-angiotensin system (RAS), Hyperuricemia may occur or frank gout may be precipitated in patients receiving thiazide therapy; because losartan decreases uric acid, losartan in combination with hydrochlorothiazide attenuates diuretic-induced hyperuricemia, Hydrochlorothiazide decreases urinary calcium excretion and may cause elevations of serum calcium; monitor calcium levels, Concomitant use of other drugs that may increase serum potassium may lead to hyperkalemia, Photosensitivity reported; instruct patients to protect skin from sun and undergo regular skin cancer screening, Therapy can cause fetal harm when administered to a pregnant woman; use of drugs that act on renin-angiotensin system during second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death, Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in first trimester have not distinguished drugs affecting renin-angiotensin system from other antihypertensive agents; when pregnancy is detected, discontinue therapy as soon as possible, Hypertension in pregnancy increases maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications (eg, need for cesarean section, post-partum hemorrhage), Hypertension increases fetal risk for intrauterine growth restriction and intrauterine death; pregnant women with hypertension should be carefully monitored and managed accordingly, Not known whether losartan is excreted in human milk, but significant levels of losartan and its active metabolite were shown to be present in rat milk; thiazides appear in human milk; because of potential for adverse effects on nursing infant, a decision should be made whether to discontinue nursing or discontinue drug, taking into account importance of drug to mother. If experienced, these tend to have a Severe expression . The recipient will receive more details and instructions to access this offer. In this trial, losartan reduced the risk of stroke (nonfatal and fatal) by 25% compared to atenolol. This website also contains material copyrighted by 3rd parties. -May increase dose if blood pressure rem… About 4% of an oral dose is excreted unchanged in urine, and about 6% is excreted in urine as the active metabolite. A 39-year-old member asked: what are the differences between losarta hctz (hydrochlorothiazide) and losartan potassium? If dose titrated upward, not to exceed final titration of 100 mg/25 mg PO qDay or 50 mg/12.5 mg PO q12hr. Losartan hctz dosage . Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem fo… This drug is available at the lowest co-pay. After a 4-week placebo run-in period, patients received once-daily telmisartan 40 mg or losartan 50 mg, with up-titration after 4 weeks to telmisartan 80 mg or losartan 100 mg, respectively, if seated trough cuff DBP >or=90 mmHg. The dose of this medicine will be different for different patients. I am on losartan 25 mg daily, lisinopril/hctz 20/12.5 daily and metroprolol 50mg at night. Check with your doctor immediately if any of the following side effects occur: Rare. Access your plan list on any device – mobile or desktop. -Encourage patients to report any lightheadedness that may occur during treatment initiation and to stop taking this drug until consulting a physician if syncope occurs. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. Usually, adults take: 50mg to 100mg once a day to treat high blood pressure and to protect their kidneys 12.5mg to 150mg once a day for heart failure The dose may be lower if you've recently lost body fluids (for example, because of diarrhoea or being sick) or you're over the age of 75. prescription products. Initial: 50 mg/12.5 mg PO qDay. The safety and efficacy of Losartan Potassium / Hydrochlorothiazide in children and adolescents under the age of 18 years have not been established. Most Adding plans allows you to compare formulary status to other drugs in the same class. This drug is not indicated for initial therapy except when hypertension is severe enough that the benefit of achieving prompt blood pressure control exceeds the risk of initiating combination therapy. I have hypertension and have been prescribed Losartan HCTZ 50-12.5 MG my BP is 158 over 95 After reading about Losartan the 12.5 Mg's is not enough to give me lower BP, according to the PDR the average ... View answer. The usual starting dose of losartan potassium and hydrochlorothiazide tablet is 50/12.5 (losartan 50 mg/hydrochlorothiazide 12.5 mg) once daily. Check with your doctor immediately if any of the following side effects occur: Less common. Initial treatment: Hydrochlorothiazide 12.5 mg-Losartan 50 mg orally once a day; if blood pressure remains uncontrolled after 2 to 4 weeks, may initiate maximum dose. Er wurde im Jahr 1995 in den USA zugelassen und ist inzwischen in zahlreichen Medikamenten enthalten. For patients who do not respond adequately to Losartan potassium/Hydrochlorothiazide 50 mg/12.5 mg, the dosage may be increased to one tablet of Losartan potassium/Hydrochlorothiazide 100 mg/25 mg (losartan 100 mg/ HCTZ 25 mg) once daily. Description and Brand Names; Before Using; Proper Use; Precautions; Side Effects; Products and services. informational and educational purposes only. Usual Pediatric Dose … The following information includes only the average doses of this medicine. Usual Adult Dose for Hypertension: Initial dose: 50 mg orally once a day. Along with its needed effects, a medicine may cause some unwanted effects. Hydrochlorothiazide 12.5 to 25 mg-Losartan 50 to 100 mg orally once a day Up to 2 tab once daily 2-4 wk later if needed. The usual starting dose of HYZAAR is 50/12.5 (losartan 50 mg/hydrochlorothiazide 12.5 mg) once daily. If you have had a recent heart attack, or you have congestive heart failure, taking losartan – hydrochlorothiazide can make symptoms of these heart conditions worse. I have hypertension and have been prescribed Losartan HCTZ 50-12.5 MG my BP is 158 over 95 After reading about Losartan the 12.5 Mg's is not enough to give me lower BP, according to the PDR the average ... View answer. Available for Android and iOS devices. The dosage can be increased after 3 weeks of therapy to a maximum of 100 mg/25 mg (losartan 100 mg/hydrochlorothiazide 25 mg) once daily as needed to control blood pressure [see CLINICAL STUDIES (14.2)]. The following information includes only the average doses of this medicine. -A patient whose blood pressure is not adequately controlled with hydrochlorothiazide or losartan monotherapy may be switched to hydrochlorothiazide 12.5 mg-losartan 50 mg orally once a day. If your dose is different, do not change it unless your doctor tells you to do so. Hydrochlorothiazide / losartan systemic 12.5 mg / 50 mg (717). This FDA-approved indication is based on the findings of the LIFE trial which compared losartan vs. atenolol in patients with hypertension and LVH. Max: 2 tab/day. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvaHl6YWFyLWxvc2FydGFuLWh5ZHJvY2hsb3JvdGhpYXppZGUtMzQyMzQw, View explanations for tiers and A combo pill vs. The usual starting dose of losartan potassium and hydrochlorothiazide tablets is 50 mg/12.5 mg (losartan 50 mg/hydrochlorothiazide 12.5 mg) once daily. Paediatric population . Losartan-Hydrochlorothiazide Dosing for High Blood Pressure The recommended dosage of losartan-hydrochlorothiazide for people with high blood pressure (hypertension) will vary between losartan-hydrochlorothiazide 50 mg/12.5 mg and losartan-hydrochlorothiazide 100 mg/25 mg once a day. Merck & Co., Inc. If affected, do not drive or take part in any activity in which you need to be alert. 2002 Side Effects. Losartan/hydrochlorothiazide, sold under the trade name Hyzaar among others, is a combination medication used to treat high blood pressure when losartan is not sufficient. Hypertensive type II diabetic patients with proteinuria ≥ 0.5 g/day . These dosages have been shown to provide respective systemic exposures (AUCs) for losartan, its active metabolite and hydrochlorothiazide that are approximately 60, 60 and 30 times greater than those achieved in humans with 100 mg of losartan potassium in combination with 25 mg of hydrochlorothiazide. [Package insert.] Losartan And Hydrochlorothiazide (Oral Route) Print. Losartan hctz dosage . By clicking send, you acknowledge that you have permission to email the recipient with this information. Detailed Losartan dosage information for adults and children. Description and Brand Names; Before Using; Proper Use; Precautions; Side Effects; Products and services. Contraindications . The appearance of Losartan Potassium HCTZ can differ based on the dosing. Your doctor may increase your dose as needed. It's FREE to register and you'll have access to drug information and much more. During the last six hours of the dosing interval, telmisartan 40 mg/HCTZ 12.5 mg and telmisartan 80 mg/HCTZ 12.5 mg reduced mean ambulatory diastolic blood pressure (DBP) to a greater extent than losartan 50 mg/HCTZ 12.5 mg (treatment differences 1.8 … Losartan Potassium/Hydrochlorothiazide Dosage & Precautions Before taking this medication, tell your doctor or pharmacist if you are allergic to losartan or hydrochlorothiazide; or if you have any other allergies. 2002 Along with its needed effects, a medicine may cause some unwanted effects. Talk to your pharmacist for more details. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. For oral dosage form (tablets): For high blood pressure: Adults—At first, one tablet once a day. It’s also used to treat diabetic nephropathy, and to reduce stroke risk. These dosages have been shown to provide respective systemic exposures (AUCs) for losartan, its active metabolite and hydrochlorothiazide that are approximately 60, 60 and 30 times greater than those achieved in humans with 100 mg of losartan potassium in combination with 25 mg of hydrochlorothiazide. Patient advice: Losartan may be administered with other antihypertensive agents, especially with diuretics (e.g.hydrochlorothiazide) (see sections 4.3, 4.4, 4.5 and 5.1). Free E-newsletter Subscribe to Housecall. Does Moderate Drinking Increase Blood Pressure in Type 2 Diabetics? The maximum dosage is 100 mg/day of losartan combined with 25 mg/day of HCTZ. Does bp meds cause you to loose weight? 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